How Long To Cook A Meatloaf At 375? | The Complete Guide

In the quest to create the quintessential comfort food, meatloaf holds a special place in the hearts and kitchens of many. Mastering the art of meatloaf making is not just about mixing the right ingredients; it’s about understanding the nuances of cooking times and temperatures to achieve that perfect blend of juicy, flavorful goodness encased in a deliciously glazed exterior. Cooking meatloaf at 375°F has become a favored method among culinary enthusiasts and home cooks alike for its ability to produce a thoroughly cooked yet moist dish. But the question remains: how long to cook a meatloaf at 375 to ensure it reaches perfection?

This article delves deep into the art and science of cooking meatloaf at 375°F, providing insights that establish a solid foundation of expertise on the topic. We explore not just the “how” but also the “why” behind the cooking time, offering valuable content that ensures your meatloaf is never dry or undercooked again. Whether you’re a seasoned chef looking to refine your technique or a home cook eager to impress at the next family dinner, understanding the intricacies of cooking time can elevate your meatloaf from mundane to magnificent.

As we embark on this culinary journey together, let’s satisfy our curiosity and unlock the secrets to making the perfect meatloaf. From exploring the impact of ingredients and loaf size on cooking time to uncovering expert tips for ensuring moistness and flavor, this article promises to enhance your cooking repertoire. So, preheat your ovens and prepare to be guided through the steps to achieving meatloaf mastery, ensuring that every slice is a testament to your culinary skills. Join us as we delve into the world of meatloaf, where patience meets passion in the pursuit of the ultimate comfort food.

A Brief History of Meatloaf: Comfort Food Through the Ages

A Brief History of Meatloaf: Comfort Food Through the Ages

While meatloaf as we know it today gained popularity in America during the Great Depression, iterations of ground meat mixtures have existed globally for centuries. Food historians trace early meatloaf-style recipes to 4th century Roman cookbook “Apicius,” which contained recipes for minced meat baked with spices and wine.

Throughout European history, scraps and leftovers were commonly mixed with breadcrumbs and baked into loaves. The classic meatloaf we love emerged in the U.S. during the early 20th century. As a budget-friendly way to stretch inexpensive ingredients like ground beef, it became a staple meal during the Depression era.

Over time, home cooks created their own unique meatloaf recipes, incorporating regional flavors and family traditions. This versatile dish truly brings people together through shared comfort and nostalgia.

Choosing Ingredients: The Building Blocks of Great Meatloaf

While recipes vary widely, a few key components create the base of most meatloaves. Let’s explore how to pick the best ingredients for building scrumptious loaf flavors.

Types of Ground Meat

Beef is the most common choice, but you can make tasty meatloaf with:

  • Ground beef: Choose 80/20 or 85/15 blends for the best fat-to-meat ratio.
  • Ground pork: Offers juicy texture and mild flavor.
  • Ground turkey or chicken: Lean options, mix with fattier meats.
  • Veggie crumbles: For meat-free versions.

Binders and Fillers

These ingredients help bind the meat mixture and add moisture. Popular choices include:

  • Breadcrumbs or crackers: Classic binders that absorb juices.
  • Oats or bread: Offer more fiber and nutrients than refined crumbs.
  • Egg: Binds and helps meatloaf hold its shape.

Mix-ins for Flavor and Texture

Veggies, cheese, herbs/spices add lots of flavor. Consider:

  • Onion, bell peppers, mushrooms, zucchini – chopped small.
  • Grated carrot or shredded spinach – for moisture.
  • Cheese like cheddar, Parmesan, or feta – crumbled.
  • Worcestershire, soy sauce, BBQ sauce – add depth.
  • Herbs like parsley, oregano, basil – chopped fresh.

Preparation Pointers for Meatloaf Success

Proper mixing, shaping, and baking technique makes all the difference. Follow these tips for the best results:

Mix Thoroughly For Even Texture

  • Use hands to combine and squash meat mixture thoroughly. This helps bind ingredients together.
  • Don’t overwork or compact too densely. Should be loose enough to shape.

Shape For Optimal Cooking

  • For even cooking, shape into a loaf about 2-3 inches high.
  • Line pan with foil and lightly grease for easy release.
  • For free-form, shape meat and seal edges on baking sheet.

Mind Oven Placement

  • Place pan in center of oven, with at least 2” around all sides.
  • Rotate pan 180° halfway through baking for even browning.

Check Temperature

  • Use instant-read thermometer to test doneness; aim for 160°F minimum.
  • Check in thickest part, away from bone/fat pockets.

How Long To Cook A Meatloaf At 375?

To cook a meatloaf at 375°F, the general guideline is to cook it for 35 to 45 minutes per pound in a conventional oven. It’s important to ensure that the internal temperature of the meatloaf reaches 155°F to 160°F for it to be fully cooked and safe to eat. Additionally, covering the meatloaf with aluminum foil during cooking can help keep it moist, but it’s recommended to remove the foil during the last 15 minutes of baking to allow the top to brown.

Enhance Flavor with Marinades, Sauces, and More

Looking to add even more flavor? Try these easy boosting tricks:

Marinate the Meat

  • Soak meat in marinade for a few hours or overnight before mixing.
  • Try wine, vinegar, broth, yogurt, citrus, soy sauce. Adds moisture and flavor.

Umami Flavor Bombs

Worcestershire sauce, tomato paste, anchovies, miso, and mushrooms all supply savory umami flavor. Add a few tablespoons or chops before mixing.

Mix and Match Glazes

Brushing on a flavorful glaze towards the end of baking gives a lovely lacquered finish. Sweet and savory choices like:

  • Ketchup, chili sauce, jalapeño jelly
  • Brown sugar, honey, maple syrup
  • Barbecue sauce, teriyaki, hoisin
  • Mustard, balsamic vinegar, fruit preserves

Global Takes: Meatloaf Around the World

Across cuisines, cooks have adapted meatloaf to suit local flavors and ingredients. For inspiration, try these worldly meatloaf recipes:

  • Lebanon – Kibbeh (bulgur, mint, spices)
  • Greece – Rolo (lamb, feta, phyllo dough)
  • Sweden – Köttfärspaj (cream sauce topping)
  • Philippines – Embutido (sausage meat, raisins)
  • Germany – Faschierter Braten (veal, pork, bacon).

Expert Tips and Troubleshooting Tricks

Expert Tips and Troubleshooting Tricks

Even experienced cooks can run into problems with meatloaf. Here are some handy fixes:

Prevent Cracking

  • Use binders like egg and breadcrumbs to hold moisture.
  • Avoid overmixing, creating air pockets that expand when heated.

Fix Soggy Texture

  • Let cool completely before slicing, allowing juices to absorb back in.
  • Blot excess grease during baking with paper towels.
  • Bake uncovered to allow moisture to evaporate.

Improve Browning

  • Brush with oil or egg wash for more even browning.
  • Broil for a couple minutes at the end to crisp the crust.

Retain Moisture

  • Start meatloaf at a higher temp (400°F) to seal in juices, then reduce heat.
  • Cover pan tightly with foil to keep moisture from escaping.

Healthy Makeover: Nutritious Options

While meatloaf has a reputation as being high in calories and fat, you can adjust the recipe for a healthier take:

  • Use at least 90% lean ground meat. Mix in chopped mushrooms for moisture.
  • Swap full-fat cheese for reduced-fat, and limit to 1⁄4 cup.
  • Add more vegetables like zucchini, spinach, carrots to up the fiber and nutrients.
  • Skip the fatty glaze and season with herbs, mustard, balsamic for flavor.
  • Opt for whole wheat panko breadcrumbs rather than white bread varieties.

Make It a Meal: Pairings and Serving Suggestions

Meatloaf makes a hearty entree, but don’t stop there! Here are ways to incorporate it into all types of meals:

Plated Dinner

  • Roasted potatoes or mashed cauliflower
  • Sauteed green beans
  • Mixed green salad


  • Ciabatta rolls, pretzel buns, or lettuce wraps
  • Cheese, lettuce, tomato, mustard, pickles

Meatloaf Tacos

  • Corn or flour tortillas
  • Shredded lettuce, pico de gallo, avocado

Breakfast Hash

  • Potatoes, peppers, onions, spinach
  • Fried eggs on top

Creative Leftover Ideas

Like chili or stew, meatloaf tastes even better the next day! Revive leftovers with:

  • Meatloaf sandwiches or sliders with melty cheese
  • Break into chunks for pasta sauce or chili
  • Slice and crisp into meatloaf “steaks”
  • Combine with cubed potatoes for meatloaf hash
  • Make “meatloaf muffins” for quick meals

Storing and Reheating Meatloaf

To safely store leftovers:

  • Allow to cool completely, then refrigerate within 2 hours.
  • Store tightly wrapped for 3-4 days.
  • Freeze up to 3 months; thaw overnight in fridge.

To reheat, choose methods like:

  • Microwave in 30 second bursts, check for hot spots.
  • Bake in oven at 350°F until warmed through, about 20 minutes.
  • Pan fry slices or cubes in skillet to crisp exterior.

Outfitting Your Meatloaf Kitchen

Outfitting Your Meatloaf Kitchen

Having the right tools makes preparing meatloaf easier. Equip your kitchen with:


  • Loaf pan, muffin tin, or rimmed baking sheet
  • Instant-read thermometer


  • Large mixing bowl
  • Rubber spatula
  • Whisk
  • Meat thermometer

Prep Tools

  • Box grater
  • Food processor


  • Parchment paper
  • Aluminum foil.

Conclusion: How long to cook a meatloaf at 375

Cooking a juicy, flavorful meatloaf at 375°F is easy with this guide! Follow these steps to prepping, cooking, and storing your meatloaf for the perfect meal every time. Remember to always use an instant read thermometer to check that the internal temperature of your loaf reads 165°F before taking it out of the oven. Serve with mashed potatoes or roasted vegetables and you’ll have a delicious dinner in no time.